Slurry handling in photo flow applications: Ir/Ni photoredox C(sp²)-C(sp³) coupling enabled by the HANU™ reactor

In our latest Organic Process Research & Development article, we report a MacMillan-type C(sp²)–C(sp³) cross-electrophile coupling. The photoredox protocol was successfully translated from batch to continuous flow thanks to implementation of Creaflow’s HANU™ reactor, enabling use of Na2CO3 as an insoluble base in flow. The combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The result is an intensified slurry process with significantly reduced reaction time and increased productivity.

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